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In secondary analyses, we observed that when the analysis was confined to the APOE ε4 carriers, the effect of donepezil was significant at 12, 24, and 36 months.
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Remove the syringe from the bottle and slowly squirt the Namenda Oral Solution into the corner of you or the patient's mouth.
The severity of dementia at entry significantly influenced the effect of donepezil on SMMSE scores, with larger benefits observed in patients with moderate disease (SMMSE score, 10 to 13) than in those with severe disease (SMMSE score, 5 to 9).
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Hypertension, hyperlipidemia, and diabetes mellitus were defined based on the need for oral anti-hypertensive, anti-hyperlipidemic, or anti-diabetic drug therapy (or insulin), respectively, prescribed by the physician.
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The safety analysis set comprised all patients who received at least 1 dose and had a postbaseline safety assessment.
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Formal pharmacokinetic studies evaluated the potential of Donepezil hydrochloride for interaction with theophylline, cimetidine, warfarin, digoxin and ketoconazole.
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Changes of some oxidative stress markers in the serum of patients with mild cognitive impairment and Alzheimer's disease.
As such, results from a CIBIC-Plus reflect clinical experience from the trial or trials in which it was used and cannot be compared directly with the results of CIBIC-Plus evaluations from other clinical trials.
In most cases these effects are non-dangerous and reversible after cessation or reduction of treatment.
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In this paper, I argue that scholars have misinterpreted Plato's epistemology in Republic 5 by confusing Plato's discussion of cognitive powers with contemporary epistemology's focus on knowledge as a cognitive state.
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Importantly, physicians can switch patients from NAMENDA to NAMENDA XR the very next day without titration, as outlined in the FDA-approved package insert.
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Visit 2 (week 7): Patients will have a neurological examination and neuropsychological testing and will fill out a quality of life questionnaire.
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Effect sizes were calculated and data were combined when appropriate.
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NAMENDA XR offers important benefits, including convenient, once-daily dosing, which is particularly meaningful for this patient population and their caregivers.
None of the subjects had clinical evidence of gastrointestinal, renal, respiratory, endocrine, haematological, neurological, psychiatric or cardiovascular system abnormalities.
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Peptic ulcer disease: Use with caution in patients at risk of ulcer disease (eg, previous history or NSAID use); cholinesterase inhibitors may increase gastric acid secretion.
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This section focuses on four diseases and disorders in which vitamin E might be involved: heart disease, cancer, eye disorders, and cognitive decline.
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Efficacy has been demonstrated in patients with mild, moderate, and severe Alzheimer's Disease ().
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Funding: The recommended budget was partially met, and the annualized recommended budget targets were met for all 3 years since the objective was introduced; therefore, the funding for this objective is on track.
Hence, these generally well tolerated drugs enhance cholinergic neurotransmission in forebrain regions and compensate for the loss of functioning brain cells.
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