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Deforolimus in combination with MK-2206 is highly effective for inhibiting castration-resistant prostate cancer (CRPC) in preclinical studies in vivo using a refined genetically engineered mouse model of the disease.
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Initial hormonal management of androgen-sensitive metastatic, recurrent, or progressive prostate cancer: 2006 update of an American Society of Clinical Oncology practice guideline.
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His research expertise is on targeted therapies for castration-resistant prostate cancer, using kinase inhibitors, androgen receptor signalling inhibitors, and autophagy modulators.
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The Panel feels that because of the substantial differences among disease stage, especially between clinical stage T1 to T2 and T3 to T4 disease, any future studies including both groups of subjects should report all data stratified by T1 to T2.
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If the cancer continues to grow, chemotherapy or immunotherapy may be recommended.
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Strategies to block androgen-receptor signaling have formed the backbone of prostate-cancer therapy since the first description of the hormonal dependence of this cancer in 1941.
The disease is either classified as acute or chronic, referring to how quickly it develops and progresses.
Some studies have demonstrated equivalence or a slight advantage for intermittent therapy; however, until larger clinical trials have been completed, intermittent hormonal therapy is still considered somewhat experimental.
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